Visualization and prediction of porosity in roller compacted ribbons
The porosity of roller compacted ribbon is recognized as an important critical quality attribute which has a huge impact on the final product quality. The purpose of this study was to investigate the use of near-infrared chemical imaging (NIR-CI) for porosity estimation of ribbons produced at different roll pressures.
Ribbon thickness influences fine generation during dry granulation
0.864 (0.003) The effect of ribbon thickness on generated percent fines by milling simulated MCC ribbons is shown in Fig. 1. When the thickness of ribbons is less than 2.55 mm, the percentage of fines increased linearly with increasing thickness. However, the percent fines generation is approximately constant when the thickness is above 2.55 mm.
Characterisation of density distributions in roller-compacted …
Roller compaction produces a compacted strip or "ribbon", which is then milled to produce granules. ... In this paper, the density distribution in roller-compacted ribbons of microcrystalline cellulose (Avicel PH102) has been examined using three different techniques: (1) sectioning; (2) micro-indentation and (3) X-ray micro-computed tomography
Ribbon density and milling parameters that determine fines fraction …
We used micro-CT to assess uniformity of density of simulated ribbon, taking advantage of its capability for density quantitation [17, 20, [33], [34], [35]].Ribbon images were reconstructed from raw X-ray micro-CT data, which showed relatively uniform density in the simulated ribbon (Fig. 2 a).The X-ray opacity of Y-Z cross sections of the stacking …
Characterisation of density distributions in roller-compacted …
Thus, different amount of powder is compacted at different positions across the roller width, which will result in a non-uniform porosity or density distribution across the width of the ribbon [4 ...
(203d) Minimization of Roller Compacted Ribbon Density
The fact that roller compaction offers relatively high throughput capacity is another driver behind this operation's increasing prevalence. Characterization of numerous roller compacted products has revealed that significant density gradient across the compacted ribbon widths, where the edges are lower in density relative to the center, …
The effect of lubrication on density distributions of roller compacted
The density variation in roller compacted ribbons was also investigated by Perera (2005) and Busies (2006). Perera (2005) found a higher density in the central part of the ribbon than that at the edges using a gravity fed compactor with sealing plates at the compaction zone.
Small Scale Mill for lab-scale roller compaction
Built for milling small amounts of a roller compacted pharmaceutical material, allowing pilot and test batches ranging from a few grams to 50gr to be milled in one pass. The Small …
Effect of roll-compaction and milling conditions on …
abstract. Dry granulation is an agglomeration process used to produce size-enlarged particles (granules), improv- ing the handling properties of powders such as flowability. …
Population balance modeling (PBM) of ribbon milling in …
Roller compaction milling process was simulated with a lab scale oscillating mill. • Ribbon properties effects on granule size distribution were studied experimentally. ... GSDs obtained from co-milling of roller compacted ribbons at two different densities were used for PBM parameter determination. PBM parameters were determined by fitting ...
MODEL-BASED DEVELOPMENT OF ROLLER COMPACTION …
The chapter provides an example of calibrating a roller compactor process model using data from trial runs on a lab-scale roller compactor. Roller-compacted ribbon size …
Energy-based analysis of cone milling process for the …
In a previous study, controlled comminution of roller compacted flakes was achieved by investigating various cone mill process parameters aimed at minimizing fines (Samanta et al., 2012). However, the energy efficiency of the different process parameters is one of the major aspects in the size reduction process especially with rising energy …
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Ribbon density and milling parameters that determine fines fraction …
There have been studies conducted on oscillating mill of roller compacted materials that have identified the effects of ribbon porosity on mill quality attributes (Mirtič and Reynolds, 2016; Olaleye et al., 2020; Sun et al., 2018). In these studies, an inverse relationship between tensile strength and porosity, and they observed that milling ...
Roller compaction: new trends, challenges and solutions
Therefore, dry granulation — and roller compaction in particular — may be the best option for these formulations. Small-scale formulation and process development. During roller compaction, a blend of the API and intragranular excipients is passed between two counter-rotating rollers to generate ribbons.
A novel method for estimating solid fraction of roller-compacted …
A simple method has been developed to estimate solid fraction or relative density of compacts using the weight of ribbons produced during roller compaction. The method provides an alternative to the commonly used dimensional measurement, especially for formulations not amenable to forming quality ribbons. Surface texture of the compaction …
The World's Largest Roller-Compacted Concrete Dams
ten largest roller compacted concrete dams"/> 10. Jin anqiao Dam, China, 2,400,000 cu m of RCC. Completed in 2011, the 160-m-tall, 640-m-long Jin anqiao Dam is located on the Jinsha River the ...
The effects of lubrication on roll compaction, ribbon milling …
By performing manufacturing-scale roller compaction using materials with diverse compressibility, we showed that the simplified, friction angle-free model …
Roller compaction: Ribbon splitting and sticking
Abstract. Roller compaction is the main technique employed in dry granulation. Ribbon sticking and splitting are among the major factors that can hinder the use of this process for some formulations. Ribbon splitting can occur either transversally (through the ribbon thickness) or longitudinally (through the ribbon width).
On a roll: Examining the principles of roller compaction in …
The ribbon is broken down into a specific granule size via a milling system, such as an oscillating mill. The purpose of dry granulation is to increase the bulk density of powders and particle size to ensure a better flow of distributed material; an important factor in the manufacturing of tablets and capsules using production equipment.
Development, Scale-Up, and Optimization of Process Parameters: Roller
32.1. Introduction. Roller compaction is the preferred method for dry granulation in the pharmaceutical industry. It is a continuous manufacturing technique introduced in the second half of the 19th century in the coal industry to compact powdered coal into briquettes. 1 The technology was later adopted by metallurgists for roll pressing …
Recent Progress in Roll Compaction Process Development …
There are several commercially available roll compactor designs developed and marketed for pharmaceutical applications. Csordas and Kleinebudde (2017) compared the …
Prediction of roller compacted ribbon solid fraction for …
Detailed view of a ribbon compacted on sinusoidal rolls. The average roll stress for sinusoidal rolls can be related to the equivalent stress for flat rolls by: (23) ... Shear stresses and material slip in high pressure roller mills. Powder Technology, 122 (2002), pp. 136-144.
Modeling and Control of Roller Compaction for …
In this study, we focus on the dynamic model of a roller compactor with one fixed and one movable roll. Three key process parameters of the roller compactor are speeds of the auger and the roll (in rpm) and the roll pressure (in MPa), and the output variables of interest are the ribbon density (in g/cm 3) and the gap width (in mm).Given …
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Roller Compaction, Granulation and Capsule Product Dissolution …
Each ribbon sample was passed through a mill (Fitzmill Model L1A, Fitzpatrick Company, Chicago, IL, USA) equipped with a 0.065-in. screen and a set of knives moving forward at 2,500 rpm. ... Both spray-dried lactose and mannitol fillers formed roller compacted ribbons with similar solid fraction and tensile strength; however, …
Prediction of roller compacted ribbon solid fraction for …
The ultimate goal of most roller compaction models is to predict ribbon solid fraction as a function of 1) process settings and 2) some readily available mechanical characteristics of the powder. ... Analysis of milling of dry compacted ribbons by distinct element method. Chemical Engineering Science, Volume 149, 2016, pp. 204-214.
Discrete element modelling of ribbon milling: A comparison …
Roller compaction followed by milling of the generated ribbons is a typical dry granulation route. It is desirable to be able to predict the size distribution of the …
Mechanistic study of the effect of roller compaction and …
A one-factor ANOVA analysis was run for each tablet SF (0.60, 0.70, and 0.80) made from and roller compacted microcrystalline cellulose (∼0.50, 0.65, and 0.84). The purpose of the ANOVA analysis was to detect if there are any statistical differences in tensile strength and yield pressure among and roller compacted …
Particle Size Distribution of Milled Ribbon
tages of roller compaction, due to the large dwell time needed for the ribbons to pass through the mill. Passing the ribbons through the .125" followed by the .050" produced …